Tonix Pharmaceuticals Holding Corp. (TNXP) shares go up more than 28% to $0.849 in the premarket trading session after it revealed the closing of the purchase of a 44-acre site in Hamilton, Montana, that will be used to develop and manufacture vaccines. In September 2020, Tonix entered into a lease agreement to purchase 40,000 square feet in Massachusetts to house their new Advanced Development Center for accelerated testing of vaccines for clinical trials.
The Montana and Massachusetts facilities are also planned to promote the production and manufacturing of candidate Tonix vaccines provided by adapted horsepox vaccines, TNX-1800, a possible COVID-19 vaccine, and TNX-801, a potential vaccine for smallpox and monkeypox.
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Tonix Pharmaceuticals is currently working on COVID-19 vaccines using two live viral vector platforms, horsepox and bovine parainfluenza virus (BPI virus). COVID-19 has four potential vaccines in development based on the horsebox vector and two vaccines based on the BPI vector. The Company’s lead vaccine, TNX-1800, is based on the horsepox vector1. The horsepox virus is thought to be very similar to the smallpox vaccine, which was developed by Dr. Edward Jenner and eradicated smallpox: the only disease ever destroyed. It was recently discovered that horsepox is nearly identical to a vaccine used in the US in the mid-1800s for smallpox2. TNX-1800 is believed to produce a predominantly T cell response to vaccination and to prevent onward transmission. In the first quarter of 2021, Tonix plans to report efficacy data from its animal challenge studies on TNX-1800.