Tonix Pharmaceuticals Holding Corp. (TNXP) shares go up more than 28% to $0.849 in the premarket trading session after it revealed the closing of the purchase of a 44-acre site in Hamilton, Montana, that will be used to develop and manufacture vaccines. In September 2020, Tonix entered into a lease agreement to purchase 40,000 square feet in Massachusetts to house their new Advanced Development Center for accelerated testing of vaccines for clinical trials.
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The Montana and Massachusetts facilities are also planned to promote the production and manufacturing of candidate Tonix vaccines provided by adapted horsepox vaccines, TNX-1800, a possible COVID-19 vaccine, and TNX-801, a potential vaccine for smallpox and monkeypox.
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Tonix Pharmaceuticals is currently working on COVID-19 vaccines using two live viral vector platforms, horsepox and bovine parainfluenza virus (BPI virus). COVID-19 has four potential vaccines in development based on the horsebox vector and two vaccines based on the BPI vector. The Company’s lead vaccine, TNX-1800, is based on the horsepox vector1. The horsepox virus is thought to be very similar to the smallpox vaccine, which was developed by Dr. Edward Jenner and eradicated smallpox: the only disease ever destroyed. It was recently discovered that horsepox is nearly identical to a vaccine used in the US in the mid-1800s for smallpox2. TNX-1800 is believed to produce a predominantly T cell response to vaccination and to prevent onward transmission. In the first quarter of 2021, Tonix plans to report efficacy data from its animal challenge studies on TNX-1800.
