Ocular Therapeutix Inc. (OCUL) stock declines during after-hour. Here’s to know why?

NAOV Stock
NAOV Stock

Ocular Therapeutix Inc. (NASDAQ: OCUL) stock rose by 3.14% at last close however the OCUL stock price declines by 4.06% in the after-market. Ocular Therapeutix is a pharmaceutical business that uses its patented bioresorbable hydrogel-based formulation technique to research, test, and commercialize novel treatments for illnesses and disorders of the eye.

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OCUL stock Current Update

Regeneron has canceled the option and licensing contract between Ocular Therapeutix and Regeneron. On August 5, 2021, the termination took effect.

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The partnership with Regeneron began in 2016 with the goal of developing and commercializing medicines that combine OCUL’s sustained-release hydrogel technology with Regeneron’s big molecule VEGF-targeting drugs to treat eye diseases. The Company and Regeneron have concentrated their efforts under a 2020 modification on the research and development of an elongated formulation of aflibercept to be administered to the suprachoroidal space for the therapy of retinal disorders.

Antony Mattessich, President and CEO of OCUL stock stated,

Although they are unhappy to see the partnership coming to an end, they are still thankful for the opportunity to engage with Regeneron with a chemical like aflibercept. Most significantly, they learnt a lot about how to combine monoclonal antibodies with their unique hydrogel and deliver them to the suprachoroidal region. This initiative has the potential to be a strategic driver for their business in the future.

OCUL stock’s Recent Development

Ocular Therapeutix has drugged the first patient in Phase 1 clinical study of OTX-TKI for the cure of wet age-related macular degeneration in the United States.

This study will look at the safety, acceptability, and biological efficacy of OTX-TKI as a therapy for wet AMD. The OTX-TKI clinical trial is being performed in the United States under an experimental IND (eIND) application at five different locations with a total of 20 randomized subjects:

  • 15 subjects will be handled with a single OTX-TKI implant involving 600 g of axitinib in conjunction with an anti-VEGF induction injection.
  • 5 subjects will be handled with a dose of aflibercept at eight-week intervals.


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